CataLysis – Joint Colloquium: Prof. Amir Hoveyda

We are very happy to welcome within the Joint Online Colloquium Series of the CataLysis network hosted by CRC 1333:

Prof. Amir H. Hoveyda
Boston College, USA/ University of Strasbourg, France

Catalytic Click Processes that Forge Functional Linkages

We cordially invite all members of the CataLysis network to the lecture.
The link to the video conference will be circulated within the CataLysis Network via E-Mail.

Abstract:
Click reactions that generate functional linkages are desirable but scarce, and among the less than a handful of catalytic options, none delivers a clippable connector. In this Lecture the development of copper(I)-catalyzed allene-ketone addition (CuAKA) will be presented. CuAKA, despite being promoted by Cu(I) complex, is mutually orthogonal to CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition) and the more recently introduced CuPDF (copper(I)-catalyzed phenoxydiazaborinine formation). These click processes can be merged for rapid and diversifiable assembly of multifunctional entities. CuAKA-generated linkages can be ruptured in dilute aqueous H₂O₂, a reactive oxygen species (ROS), the higher concentration of which in a cell foreshadows diseases such as cancer and diabetes. CuAKA has been used for efficient linking of anti-cancer agent camptothecin to unprotected penetratin, a cell-penetrating peptide, with payload release occurring in a 68 μM aqueous solution of H₂O₂ at 37 °C.